Futurama

After spending a few years researching science fiction, Groening got together with Simpsons writer/producer David X. Cohen (still known as David S. Cohen at the time) in 1997 and developed Futurama, an animated series about life in the year 3000. By the time they pitched the series to Fox in April 1998, Groening and Cohen had composed many characters and storylines; Groening claimed they had gone "overboard" in their discussions. Groening described trying to get the show on the air as "by far the worst experience of grown-up life." The show premiered on March 28, 1999. Groening's sole writing credit for the show was the premiere episode, "Space Pilot 3000", co-written with Cohen.

David X. Cohen and Groening at the Futurama panel of Comic-Con 2009.
After four years on the air, the show was canceled by Fox. In a similar situation as Family Guy, however, strong DVD sales and very stable ratings on Adult Swim brought Futurama back to life. When Comedy Central began negotiating for the rights to air Futurama reruns, Fox suggested that there was a possibility of also creating new episodes. When Comedy Central committed to sixteen new episodes, it was decided that four straight-to-DVD films—Bender's Big Score (2007), The Beast with a Billion Backs (2008), Bender's Game (2008) and Into the Wild Green Yonder (2009)—would be produced.Since no new Futurama projects were in production, the movie Into the Wild Green Yonder was designed to stand as the Futurama series finale. However, Groening had expressed a desire to continue the Futurama franchise in some form, including as a theatrical film. In an interview with CNN, Groening said that "we have a great relationship with Comedy Central and we would love to do more episodes for them, but I don't know...We're having discussions and there is some enthusiasm but I can't tell if it's just me."
On June 9, 2009, it was confirmed that Comedy Central had picked up the show for 26 new episodes that will begin airing in 2010.